重症急性胰腺炎入院后48小时内肠内营养

Enteralnutritionprovidedwithin48hoursafteradmissioninsevereacutepancreatitisAsystematicreviewandmeta-analysis

重症急性胰腺炎入院后48小时内肠内营养的系统评价及Meta分析

Purpose

Whethertoconductenteralnutritioninpatientswithsevereacutepancreatitis(SAP)duringtheactivephaseofintestinalstressortofeedduringremissionremainscontroversial.Thisstudywasaimedtoevaluatetheefficacyandsafetyofenteralnutritionwithin48hoursafteradmissioninthepatientswithSAPorpredictedsevereacutepancreatitis(pSAP).

对于重症急性胰腺炎(SAP)患者，在肠道应激活动期进行肠内营养还是在缓解期进食仍存在争议。本研究的目的是评价重症急性胰腺炎(PSAP)患者入院后48小时内肠内营养的有效性和安全性

Methods

WesearchedPubMed,EMBASE,WebofScience,andtheCochraneLibrarybeforeDecember.Randomizedcontrolledtrialsofearlyenteralnutrition(startingwithin48hoursafteradmission)versuslateenteralnutritionortotalparentalnutritioninsevereacutepancreatitisorpredictedsevereacutepancreatitiswereselected.

年12月之前，我们搜索了PubMed、EMBASE、WebofScience和Cochranelibrary。早期肠内营养(入院后48小时内开始)与晚期随机对照试验，在重症急性胰腺炎或预测的重症急性胰腺炎（pSAP）中选择肠内营养或全肠外营养。

Results

Tenrandomizedcontrolledtrialscontainingpatientswereincluded.ComparingearlyenteralnutritiontolateenteralnutritionortotalparentalnutritioninSAPorpSAP,thepooledriskratioswere0.53(95%confidenceinterval[CI]0.35–0.81,P=.)formortality,0.58(95%CI0.43–0.77,P=.)formultipleorganfailure(MOF),0.50(95%CI0.33–0.75,P=.)foroperativeintervention,0.75(95%CI0.61–0.93,P=.)forsystemicinfection,0.42(95%CI0.26–0.69,P=.)forlocalseptic







































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